Standardized sweat testing for the laboratory diagnosis of cystic fibrosis.
The Macroduct system is the Webster Sweat Inducer, and the Macroduct Sweat Collector. Together they have revolutionized the laboratory sweat test for cystic fibrosis, and have brought early intervention to thousands of CF patients around the world. The heart of this system is simplicity.
The 1959 pad absorption method of Gibson and Cooke, which introduced pilocarpine iontophoresis for sweat stimulation, is generally regarded as the reference method for sweat testing. Although generally free of intrinsic error, the method is long, tedious, requires a great deal of technical skill to administer and therefore invites human error. The Macroduct System has forever eliminated the errors inherent in all previously used methods and offers an easily standardized test.
The Webster sweat inducer and Macroduct sweat collector produce a pure specimen of eccrine secretion for analysis by using either chloride analysis with a Chloridometer or total electrolyte analysis with the Sweat-Chek Analyzer. These instruments provide simple and accurate analysis of the specimen. Together with the Macroduct Sweat Collection System, they have become the world standard, used by thousands of labs worldwide.
Macroduct is approved for sweat stimulation and collection by the U.S. Cystic Fibrosis Foundation, and is rapidly replacing the pad absorption method where laboratories want standardized tests. With the Macroduct system, sweat testing is both accurate and simple.